A patient on sertraline and linezolid develops fever, hyperreflexia, clonus, and agitation consistent with serotonin syndrome. Besides stopping the offending agents, which drug acts as a serotonin antagonist and is the specific antidote for this condition?

• A Bromocriptine
• B Dantrolene
• C Flumazenil
• D Cyproheptadine ✓

Explanation

Cyproheptadine is a 5-HT2A antagonist and is the specific antidote for serotonin syndrome. Bromocriptine is a dopamine agonist used for neuroleptic malignant syndrome. Dantrolene is a muscle relaxant used for malignant hyperthermia or NMS rigidity. Flumazenil is a benzodiazepine antagonist used in BZD overdose.

Reference: Katzung and Trevor's Pharmacology, 12th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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