Which antidepressant must be avoided in a patient with a history of a seizure disorder because it lowers the seizure threshold in a dose-dependent manner?
- A Mirtazapine
- B Trazodone
- C Bupropion ✓
- D Duloxetine
Correct answer: C. Bupropion
Explanation
Bupropion is a norepinephrine-dopamine reuptake inhibitor with no serotonergic activity, and its best-known dose-related toxicity is seizures; incidence rises sharply above the recommended daily dose, and it is contraindicated in seizure disorders, eating disorders, and abrupt alcohol withdrawal. Duloxetine and other SSRIs and SNRIs are relatively seizure-safe, which distinguishes them from bupropion in this setting.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.