Which drug is the recommended initial parenteral therapy to terminate an episode of established status epilepticus?
- A IV phenytoin loading dose
- B IV levetiracetam loading dose
- C IV lorazepam ✓
- D IV sodium valproate
Correct answer: C. IV lorazepam
Explanation
Initial therapy of established status epilepticus is a benzodiazepine given intravenously, classically IV lorazepam, which terminates the seizure in the majority of patients. Lorazepam is preferred over diazepam because its lipid redistribution is slower, giving a longer duration of protective action and less risk of early seizure recurrence. Phenytoin, valproate, or levetiracetam are second-line agents used after the benzodiazepine to prevent recurrence, not to abort the ongoing seizure.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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