A 28-year-old man with depression and a history of binge eating disorder is started on bupropion. Which factor increases his risk of seizures with this drug?
- A Concurrent use of omeprazole
- B History of bulimia nervosa ✓
- C Hypothyroidism
- D Hypertension
Correct answer: B. History of bulimia nervosa
Explanation
Bupropion lowers the seizure threshold. The risk is significantly increased in patients with eating disorders such as bulimia nervosa or anorexia nervosa, as well as in those with head trauma or alcohol withdrawal. Dose reduction is essential in these populations.
Reference: Stahl's Essential Psychopharmacology, 5th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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