The intravenous benzodiazepine preferred as the initial agent for termination of active seizures in adults because of its rapid onset combined with the longest duration of anticonvulsant action among the class is:

• A Midazolam
• B Clonazepam
• C Diazepam
• D Lorazepam ✓

Explanation

IV lorazepam is the standard first-line benzodiazepine in status epilepticus because its lipid solubility is lower than diazepam's, producing slower brain entry but much less redistribution to fat, hence a longer duration of seizure protection (12 to 24 hours versus about 20 minutes for diazepam). Diazepam has a longer terminal half-life only because of active metabolites, but redistribution terminates its clinical effect quickly.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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