Which benzodiazepine is preferred for status epilepticus via the intravenous route due to its rapid onset and relatively long duration compared to others by this route?
- A Alprazolam
- B Lorazepam ✓
- C Midazolam
- D Clobazam
Correct answer: B. Lorazepam
Explanation
Lorazepam IV is the preferred first-line agent for status epilepticus because of its rapid CNS onset and a longer duration of antiseizure effect (12–24 hours) compared to diazepam, which redistributes rapidly from the brain due to its high lipophilicity. Midazolam IM is preferred when IV access is unavailable. Alprazolam is used for anxiety and panic disorder, not status epilepticus. Clobazam is used as an adjunctive oral agent.
Reference: KD Tripathi, Essentials of Medical Pharmacology, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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