Which first-generation sulfonylurea potentiates the action of antidiuretic hormone and has been used therapeutically in partial central diabetes insipidus?
- A Chlorpropamide ✓
- B Tolbutamide
- C Glipizide
- D Gliclazide
Correct answer: A. Chlorpropamide
Explanation
Chlorpropamide uniquely potentiates ADH action on the collecting duct and was historically used in partial central diabetes insipidus. The same property causes water retention and hyponatremia as an adverse effect, along with a disulfiram-like alcohol flushing reaction. Tolbutamide lacks significant ADH potentiation, and the second-generation agents glipizide and gliclazide were developed specifically to avoid these first-generation toxicities.
Reference: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 14th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.