A 48-year-old woman with type 2 diabetes (HbA1c 8.1%) and Crohn's disease in remission is being considered for an oral hypoglycemic. Which drug is contraindicated given her inflammatory bowel disease?
- A Acarbose ✓
- B Gliclazide
- C Sitagliptin
- D Pioglitazone
Correct answer: A. Acarbose
Explanation
Acarbose (and miglitol) are contraindicated in inflammatory bowel disease. They cause excessive gas production from bacterial fermentation of undigested carbohydrates in the colon, which can worsen IBD symptoms and cause abdominal distension. The other agents (DPP-4 inhibitors, sulfonylureas, TZDs) are not contraindicated in Crohn's disease.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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