Which insulin preparation is most suitable for use in continuous subcutaneous insulin infusion (insulin pump therapy)?

• A Regular (soluble) insulin
• B Insulin lispro or aspart (rapid-acting analogues) ✓
• C Insulin glargine (U-100)
• D Insulin detemir

Explanation

Rapid-acting insulin analogues (lispro, aspart, glulisine) are preferred for insulin pump therapy because their rapid onset and short duration allow precise matching of bolus doses to meal carbohydrate content and enable accurate basal rate programming. Glargine and detemir are long-acting basal insulins not suited for pump use because their precipitation at pH 7.4 or self-aggregation properties may clog the pump catheter.

Reference: KD Tripathi, Essentials of Medical Pharmacology, 8th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.