Which antiplatelet drug is a monoclonal antibody fragment directed against the glycoprotein IIb/IIIa receptor?
- A Tirofiban
- B Abciximab ✓
- C Eptifibatide
- D Prasugrel
Correct answer: B. Abciximab
Explanation
Abciximab is the Fab fragment of a chimeric human-murine monoclonal antibody against the GPIIb/IIIa receptor. By occupying the receptor it prevents fibrinogen and von Willebrand factor bridging adjacent platelets, blocking the final common pathway of aggregation. Tirofiban is a small molecule non-peptide antagonist and eptifibatide is a cyclic peptide, so both are reversible small antagonists rather than antibodies. Prasugrel is a thienopyridine acting upstream at P2Y12.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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