Which oral anticoagulant requires no routine coagulation monitoring partly because about 80 percent of the absorbed dose is eliminated unchanged by the kidneys, making renal function its key safety determinant?

• A Dabigatran etexilate ✓
• B Rivaroxaban
• C Warfarin
• D Edoxaban

Explanation

Dabigatran etexilate is a prodrug converted to active dabigatran, and roughly 80 percent of the active drug is cleared renally unchanged. This heavy renal dependence means accumulation and bleeding in renal impairment, so creatinine clearance must be assessed before starting and periodically thereafter. Rivaroxaban and edoxaban are also partly renal but to a lesser degree (about one third), and warfarin is hepatically metabolized.

Reference: Katzung Basic and Clinical Pharmacology, 15th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.