Doxycycline is preferred over tetracycline for many infections partly because it has less photosensitivity than older tetracyclines. Which tetracycline is associated with the highest incidence of phototoxicity?
- A Doxycycline
- B Demeclocycline ✓
- C Minocycline
- D Tigecycline
Correct answer: B. Demeclocycline
Explanation
Demeclocycline has the highest incidence of phototoxicity among tetracyclines. Doxycycline and minocycline are less phototoxic. Tigecycline is a glycylcycline with a different side effect profile. This distinction is clinically relevant when prescribing tetracyclines to patients with significant sun exposure.
Reference: Katzung Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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