Which tetracycline derivative was formerly used specifically for its ability to induce nephrogenic diabetes insipidus, and was therefore employed in the management of inappropriate ADH secretion?
- A Demeclocycline ✓
- B Minocycline
- C Doxycycline
- D Tigecycline
Correct answer: A. Demeclocycline
Explanation
Demeclocycline uniquely blocks ADH action on the collecting duct and produces a reversible nephrogenic diabetes insipidus, a side effect exploited therapeutically in the syndrome of inappropriate ADH secretion before more predictable options became available. Doxycycline and minocycline do not produce this effect consistently enough for clinical use, and tigecycline is a parenteral glycylcycline never used for SIADH.
Reference: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 14th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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