Which tetracycline can be used without dose adjustment in significant renal failure because it is cleared by nonrenal routes including fecal elimination?
- A Tetracycline
- B Demeclocycline
- C Doxycycline ✓
- D Oxytetracycline
Correct answer: C. Doxycycline
Explanation
Doxycycline is predominantly eliminated unchanged in feces and via chelation in the intestinal lumen, so its half-life is little altered even in advanced renal failure, making it the safest tetracycline in uremia. The older tetracyclines are renally excreted and accumulate, producing azotemia through their antianabolic effect on protein synthesis. Minocycline is hepatically metabolized but accumulates less predictably and causes vestibular effects.
Reference: Katzung's Basic and Clinical Pharmacology, 15th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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