According to the WHO multidrug therapy schedule followed in India, which correctly describes the adult multibacillary leprosy regimen?

• A Rifampicin 600 mg monthly supervised, clofazimine 300 mg monthly, dapsone 250 mg twice weekly, for 12 months
• B Rifampicin 450 mg monthly supervised, dapsone 100 mg daily, for 6 months
• C Rifampicin 600 mg daily, dapsone 100 mg daily, clofazimine 100 mg daily, for 24 months
• D Rifampicin 600 mg monthly supervised, clofazimine 300 mg monthly plus 50 mg daily, dapsone 100 mg daily, for 12 months ✓

Explanation

Multibacillary MDT comprises rifampicin 600 mg once monthly supervised, clofazimine 300 mg once monthly supervised plus 50 mg self-administered daily, and dapsone 100 mg self-administered daily, for 12 months. Option B describes the paucibacillary regimen of 6 months without clofazimine. Daily rifampicin is never used in MDT because of toxicity and cost, and dapsone is given daily, not intermittently.

Reference: Park's Textbook of Preventive and Social Medicine, 27th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.