A 6-month-old infant born to a non-immunized mother presents with a continuous machinery murmur, bilateral cataracts, and sensorineural hearing loss. Which maternal infection during early pregnancy is most likely responsible?
- A Toxoplasmosis
- B Cytomegalovirus
- C Rubella ✓
- D Syphilis
Correct answer: C. Rubella
Explanation
Congenital rubella syndrome classically presents with the triad of patent ductus arteriosus (machinery murmur), cataracts, and sensorineural deafness. Maternal infection in the first trimester carries the highest risk. Toxoplasmosis causes hydrocephalus and intracranial calcifications; CMV causes periventricular calcifications; syphilis causes rhinitis and periostitis.
Reference: Nelson Textbook of Pediatrics, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.