Which of the following is the LEAST common major manifestation of acute rheumatic fever?
- A Carditis
- B Migratory polyarthritis
- C Subcutaneous nodules ✓
- D Sydenham chorea
Correct answer: C. Subcutaneous nodules
Explanation
Subcutaneous nodules occur in fewer than 10 percent of attacks and are the rarest major manifestation. They are firm, painless, mobile, and located over extensor surfaces such as elbows and knees, and their presence almost always signals coexisting carditis. Carditis and polyarthritis are far more frequent, and chorea appears in roughly 10 to 30 percent of patients. Because nodules so rarely occur alone, they add little diagnostic weight despite being a major criterion.
Reference: Nelson Textbook of Pediatrics, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.