A 28-week preterm neonate is receiving total parenteral nutrition. On day 10, the infant develops temperature instability, abdominal distension, and lethargy. Blood culture grows coagulase-negative staphylococcus. What is the MOST common risk factor for this infection?
- A Lack of maternal intrapartum antibiotic prophylaxis
- B Presence of a central venous catheter ✓
- C Prolonged rupture of membranes beyond 18 hours
- D Meconium aspiration at delivery
Correct answer: B. Presence of a central venous catheter
Explanation
Coagulase-negative staphylococcus is the most common organism causing late-onset sepsis in preterm neonates, primarily associated with central venous catheter colonization. Lack of intrapartum antibiotics and prolonged rupture of membranes are risk factors for early-onset sepsis. Meconium aspiration is not a recognized risk factor for nosocomial bloodstream infection.
Reference: Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 8th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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