A neonate born at 28 weeks gestation develops progressive respiratory distress within 4 hours of birth, grunting, intercostal retractions, and a chest X-ray showing bilateral diffuse ground-glass opacification with air bronchograms. Surfactant therapy is given. Which surfactant preparation is derived from bovine lung lavage and contains SP-B and SP-C proteins?
- A Beractant (Survanta)
- B Poractant alfa (Curosurf) ✓
- C Calfactant (Infasurf)
- D Lucinactant (Surfaxin)
Correct answer: B. Poractant alfa (Curosurf)
Explanation
Poractant alfa (Curosurf) is derived from porcine (not bovine) lung mincing and extraction, containing SP-B and SP-C. Calfactant (Infasurf) is a bovine lung lavage–derived surfactant containing SP-B and SP-C. Beractant (Survanta) is a modified bovine lung extract (minced). Lucinactant (Surfaxin) is the only fully synthetic surfactant containing a synthetic SP-B analogue (sinapultide/KL4 peptide). The question stem specifies bovine lung lavage, which identifies Calfactant. Curosurf, though the most commonly used globally, is porcine.
Reference: Ghai Essential Pediatrics, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.