A preterm neonate at 28 weeks gestation is born with severe respiratory distress. Chest X-ray shows a 'ground glass' appearance with air bronchograms and reduced lung volumes. Surfactant therapy is initiated. Which surfactant preparation is derived from bovine lung lavage and contains SP-B and SP-C proteins?
- A Poractant alfa (Curosurf)
- B Beractant (Survanta)
- C Calfactant (Infasurf) ✓
- D Lucinactant (Surfaxin)
Correct answer: C. Calfactant (Infasurf)
Explanation
Calfactant (Infasurf) is derived from bovine lung lavage and contains the hydrophobic surfactant proteins SP-B and SP-C. Beractant (Survanta) is derived from minced bovine lungs and contains SP-B and SP-C but is a lung extract (not lavage). Poractant alfa (Curosurf) is from porcine lung lavage. Lucinactant (Surfaxin) is a synthetic preparation containing sinapultide, a peptide mimicking SP-B.
Reference: Ghai Essential Pediatrics, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.