A neonate with symptomatic congenital CMV infection and CNS involvement is started on antiviral therapy. What is the recommended duration of treatment with valganciclovir?
- A 6 weeks
- B 6 months ✓
- C 3 months
- D 12 months
Correct answer: B. 6 months
Explanation
Symptomatic congenital cytomegalovirus infection with central nervous system involvement requires treatment with valganciclovir or ganciclovir for a total duration of 6 months. This extended course has been shown to improve both hearing and neurodevelopmental outcomes. Shorter courses are insufficient to prevent disease progression, while longer courses significantly increase the risk of toxicity without added benefit.
Reference: Nelson Textbook of Pediatrics, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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