A term neonate is diagnosed with congenital syphilis based on a positive VDRL and radiographic evidence of periostitis. Which is the recommended treatment regimen for this infant?
- A Aqueous crystalline penicillin G IV for 10 days ✓
- B Benzathine penicillin G IM single dose
- C Ceftriaxone IV for 14 days
- D Aqueous penicillin G IV for 14 days
Correct answer: A. Aqueous crystalline penicillin G IV for 10 days
Explanation
The standard treatment for symptomatic congenital syphilis or infants with abnormal cerebrospinal fluid is aqueous crystalline penicillin G administered intravenously for 10 days. Benzathine penicillin G is reserved only for completely asymptomatic infants with normal CSF and assured follow-up. Ceftriaxone is not the standard of care for congenital syphilis due to variable efficacy and potential toxicity.
Reference: Nelson Textbook of Pediatrics, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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