A neonate born to a GBS-positive mother who received intrapartum penicillin 1 hour before delivery now shows signs of respiratory distress at 6 hours of life. What is the recommended initial antibiotic regimen for presumed early-onset GBS sepsis in this neonate?

• A Ampicillin + gentamicin ✓
• B Vancomycin + gentamicin
• C Cefotaxime alone
• D Penicillin G alone

Explanation

The empirical antibiotic regimen for suspected early-onset neonatal sepsis (including GBS) is ampicillin plus gentamicin. Ampicillin provides coverage for GBS and Listeria, while gentamicin provides synergistic gram-negative coverage. Intrapartum prophylaxis given less than 4 hours before delivery is considered inadequate, so this neonate requires evaluation and treatment. Penicillin G alone would be used for confirmed GBS sepsis once cultures confirm the organism.

Reference: Ghai Essential Pediatrics, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.