A neonate born to an HBsAg-positive mother should receive which specific combination at birth for optimal prevention of perinatal hepatitis B transmission?
- A HBV vaccine alone within 12 hours
- B HBIG alone within 12 hours
- C HBV vaccine + HBIG (hepatitis B immunoglobulin) simultaneously at different sites within 12 hours of birth ✓
- D HBV vaccine within 24 hours; HBIG within 7 days
Correct answer: C. HBV vaccine + HBIG (hepatitis B immunoglobulin) simultaneously at different sites within 12 hours of birth
Explanation
For infants born to HBsAg-positive mothers, the combination of HBV vaccine AND HBIG administered simultaneously at different sites within 12 hours of birth provides >90% efficacy in preventing perinatal transmission. HBIG provides immediate passive immunity while active vaccination builds long-term protection. Vaccine alone without HBIG is significantly less effective for infants of HBsAg-positive mothers; delayed administration beyond 12 hours reduces efficacy.
Reference: Ghai Essential Pediatrics, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.