Which of the following medications is a recognized cause of bilateral gynecomastia through antiandrogen action?

• A Spironolactone ✓
• B Amoxicillin
• C Salbutamol
• D Paracetamol

Explanation

Spironolactone causes gynecomastia by blocking androgen receptors and increasing peripheral aromatization of testosterone to estradiol; it is among the most frequently implicated drugs along with cimetidine, ketoconazole, isoniazid, omeprazole, and marijuana. Amoxicillin, salbutamol, and paracetamol have no recognized association with gynecomastia. Recognizing drug-induced causes matters clinically because discontinuing the offending agent usually reverses the breast enlargement without hormonal workup.

Reference: Katzung's Basic and Clinical Pharmacology, 16th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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