During the evaluation of a 13-year-old girl with short stature, which finding would be most consistent with Turner syndrome rather than constitutional delay of growth and puberty?

• A Elevated FSH level ✓
• B Delayed bone age by 2 years
• C Family history of delayed puberty
• D Normal growth velocity for bone age

Explanation

Turner syndrome (45,X) is characterized by primary ovarian insufficiency causing markedly elevated FSH levels due to lack of ovarian feedback. Constitutional delay shows low or prepubertal FSH with delayed bone age and often a family history of delayed puberty, with normal growth velocity for bone age. Delayed bone age, family history, and normal growth velocity for bone age all favor constitutional delay over Turner syndrome.

Reference: Nelson Textbook of Pediatrics, 21st ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.