Takayasu arteritis preferentially involves which type of vessels and which age/sex group?

• A Medium-sized arteries in elderly men; associated with HBV
• B Large arteries (aorta and branches) in young women; leads to 'pulseless disease' ✓
• C Small vessels and venules in elderly adults; associated with ANCA
• D Coronary and renal arteries in children; associated with Kawasaki disease

Explanation

Takayasu arteritis is a granulomatous vasculitis of large vessels — primarily the aorta and its major branches — affecting young women (under 40), especially in East Asia. Intimal fibrosis and medial inflammation cause stenosis and thrombosis, leading to arm claudication and absent pulses ('pulseless disease'). Constitutional symptoms precede vascular occlusion. Polyarteritis nodosa involves medium arteries with HBV association.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.