A 55-year-old woman develops numerous rapidly enlarging seborrheic keratoses over her trunk within a few months. Further workup reveals an adenocarcinoma of the stomach. What is this cutaneous paraneoplastic sign called?
- A Acanthosis nigricans
- B Sign of Leser-Trelat ✓
- C Sweet syndrome
- D Necrolytic migratory erythema
Correct answer: B. Sign of Leser-Trelat
Explanation
The sign of Leser-Trelat is the sudden eruption or rapid increase in number and size of seborrheic keratoses, most often linked to gastric, colonic, or breast adenocarcinoma, frequently coexisting with acanthosis nigricans. Option A is tempting because both signs share the same underlying malignancies, but acanthosis nigricans presents as velvety hyperpigmentation of flexural skin, not eruptive keratoses. Necrolytic migratory erythema belongs to glucagonoma.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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