Pathology · Neoplasia (Classification, Carcinogenesis, Tumor Markers, Paraneoplastic)

A 60-year-old man with newly diagnosed pancreatic adenocarcinoma develops recurrent, migratory superficial thrombophlebitis in his arms and chest wall. This paraneoplastic phenomenon is known as:

  • A Sweet syndrome
  • B Lambert-Eaton syndrome
  • C Stiff-person syndrome
  • D Trousseau syndrome
Correct answer: D. Trousseau syndrome

Explanation

Trousseau syndrome is a paraneoplastic hypercoagulable state presenting as migratory thrombophlebitis, classically associated with pancreatic and lung adenocarcinomas. Lambert-Eaton syndrome is associated with small cell lung carcinoma and causes muscle weakness. Sweet syndrome is febrile neutrophilic dermatosis. Stiff-person syndrome is associated with anti-amphiphysin antibodies.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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