A 58-year-old woman with new-onset diabetes presents with a migrating, erythematous, scaly rash on the perineum and groin, glossitis, and weight loss. A pancreatic mass is identified. Which tumor is most likely responsible?
- A Insulinoma
- B Glucagonoma ✓
- C Gastrinoma
- D Somatostatinoma
Correct answer: B. Glucagonoma
Explanation
Necrolytic migratory erythema is the characteristic paraneoplastic rash of glucagonoma, an alpha-cell pancreatic neuroendocrine tumor. It presents with dermatitis, diabetes, depression, and deep vein thrombosis. Insulinoma causes hypoglycemia. Gastrinoma causes Zollinger-Ellison syndrome. Somatostatinoma causes diabetes, cholelithiasis, and steatorrhea.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.