A 63-year-old man with adenocarcinoma of the pancreas develops recurrent, migrating superficial venous thromboses involving first the saphenous region, then the cephalic vein, then the femoral vein, despite anticoagulation. This paraneoplastic syndrome is known as:

• A Budd-Chiari syndrome
• B Trousseau syndrome ✓
• C Marantic endocarditis
• D Lemierre syndrome

Explanation

Trousseau syndrome is migratory thrombophlebitis associated with mucin-secreting adenocarcinomas, classically of the pancreas, mediated by tumor-derived procoagulants and platelet activation. Marantic endocarditis is nonbacterial thrombotic vegetations on cardiac valves, a related hypercoagulable manifestation but a distinct entity, which kills option C. Budd-Chiari is hepatic vein thrombosis, and Lemierre syndrome is septic jugular thrombophlebitis due to Fusobacterium after pharyngitis.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.