Which chromosomal translocation places the MYC proto-oncogene under the control of the immunoglobulin heavy chain promoter, a finding characteristic of endemic Burkitt lymphoma?
- A t(8;14) ✓
- B t(11;14)
- C t(15;17)
- D t(14;18)
Correct answer: A. t(8;14)
Explanation
t(8;14)(q24;q32) juxtaposes MYC on chromosome 8 with the IgH locus on chromosome 14, driving constitutive MYC expression in B cells. t(14;18) activates BCL2 in follicular lymphoma, t(11;14) activates cyclin A1 in mantle cell lymphoma, and t(15;17) creates PML-RARA in acute promyelocytic leukemia, so each distractor pairs a real translocation with the wrong disease.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.