Alpha-fetoprotein (AFP) is a clinically useful tumor marker for which combination of tumors?
- A Seminoma and prostatic carcinoma
- B Choriocarcinoma and embryonal carcinoma
- C Hepatocellular carcinoma and yolk sac tumor ✓
- D Teratoma and dysgerminoma
Correct answer: C. Hepatocellular carcinoma and yolk sac tumor
Explanation
AFP is elevated in hepatocellular carcinoma and yolk sac (endodermal sinus) tumors of the gonad. Seminoma and dysgerminoma are AFP-negative. Choriocarcinoma secretes beta-hCG not AFP. Embryonal carcinoma can have modest AFP elevation but choriocarcinoma does not.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.