A 55-year-old woman has a uterine mass. Serum CA-125 is markedly elevated. Which histological type of ovarian tumor characteristically produces this marker?
- A Mucinous cystadenocarcinoma
- B Serous cystadenocarcinoma ✓
- C Endodermal sinus (yolk sac) tumor
- D Granulosa cell tumor
Correct answer: B. Serous cystadenocarcinoma
Explanation
CA-125 (MUC16) is most characteristically elevated in serous carcinoma of the ovary and peritoneum, and is used for monitoring treatment response and detecting recurrence. Mucinous tumors more typically elevate CA-19-9 and CEA. Yolk sac tumors produce AFP, and granulosa cell tumors produce inhibin and estradiol. CA-125 elevation also occurs in endometrial carcinoma and benign conditions such as endometriosis and PID.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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