A tumor is described as having irregular islands of epithelial cells embedded in a dense fibrous stroma, making it hard to the touch. This histological pattern is best described as:
- A Medullary carcinoma
- B Mucinous (colloid) carcinoma
- C Scirrhous carcinoma (desmoplastic reaction) ✓
- D Papillary carcinoma
Correct answer: C. Scirrhous carcinoma (desmoplastic reaction)
Explanation
Scirrhous carcinoma is characterized by sparse malignant epithelial cells surrounded by abundant dense fibrous (desmoplastic) stroma, producing a hard, gritty consistency. This is classic for infiltrating ductal carcinoma of the breast. Medullary carcinoma has abundant tumor cells with scant stroma. Mucinous carcinoma has mucin pools. Papillary carcinoma has finger-like projections.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.