Alpha-fetoprotein (AFP) is elevated in hepatocellular carcinoma. Which other malignant tumor characteristically produces AFP as a tumor marker?
- A Choriocarcinoma
- B Endodermal sinus (yolk sac) tumor ✓
- C Seminoma
- D Mature teratoma
Correct answer: B. Endodermal sinus (yolk sac) tumor
Explanation
Endodermal sinus (yolk sac) tumor is the germ cell tumor classically associated with markedly elevated AFP, reflecting its recapitulation of yolk sac differentiation. Choriocarcinoma produces beta-hCG, not AFP. Seminoma produces PLAP and beta-hCG in small amounts. Mature teratoma does not produce AFP.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.