A 45-year-old man is found to have elevated serum alpha-fetoprotein (AFP). Which of the following is the LEAST likely source?
- A Hepatocellular carcinoma
- B Yolk sac tumor of the testis
- C Colonic adenocarcinoma ✓
- D Hepatic regeneration following acute hepatitis
Correct answer: C. Colonic adenocarcinoma
Explanation
AFP is elevated in hepatocellular carcinoma, yolk sac (endodermal sinus) tumors, and physiologically during hepatic regeneration. Colonic adenocarcinoma is associated with CEA (carcinoembryonic antigen), not AFP; elevated AFP is not a recognized feature of colorectal cancer.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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