Oncogene amplification in neuroblastoma is detected by FISH showing double minutes and homogeneously staining regions (HSRs). Which gene is amplified?
- A MYCN ✓
- B HER2/ERBB2
- C RET
- D MDM2
Correct answer: A. MYCN
Explanation
MYCN (N-Myc) amplification is the hallmark oncogene amplification in neuroblastoma; more than 10 copies per haploid genome confer high-risk disease and poor prognosis. Double minutes and HSRs are cytogenetic manifestations of gene amplification. HER2 amplification characterises breast and gastric cancers. RET mutations cause hereditary medullary thyroid carcinoma and MEN2. MDM2 amplification is the prototypic finding in well-differentiated/dedifferentiated liposarcoma.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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