In oncogenesis, the RET proto-oncogene is characteristically mutated (point mutation or rearrangement) in all of the following EXCEPT:
- A Follicular thyroid carcinoma (PAX8-PPARG fusion) ✓
- B Multiple endocrine neoplasia type 2A
- C Multiple endocrine neoplasia type 2B
- D Papillary thyroid carcinoma (RET/PTC rearrangement)
Correct answer: A. Follicular thyroid carcinoma (PAX8-PPARG fusion)
Explanation
RET proto-oncogene is involved in MEN2A and MEN2B (germline point mutations) and in papillary thyroid carcinoma (somatic RET/PTC chromosomal rearrangements). Follicular thyroid carcinoma is instead characterised by the PAX8-PPARG translocation t(2;3) and RAS mutations, not RET rearrangements.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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