Which tumor marker is MOST specifically elevated in granulosa cell tumor of the ovary and can be used for monitoring recurrence?
- A CA-125
- B AFP
- C Inhibin B ✓
- D LDH
Correct answer: C. Inhibin B
Explanation
Granulosa cell tumors of the ovary are sex cord-stromal tumors that produce inhibin B (and inhibin A), making serum inhibin B the preferred marker for diagnosis and monitoring recurrence. CA-125 is elevated mainly in epithelial ovarian tumors. AFP is the marker for yolk sac tumor, and LDH is used for dysgerminoma.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.