Anti-Ri antibody (ANNA-2) is a paraneoplastic antibody most characteristically associated with which tumor?
- A Small cell lung carcinoma
- B Breast carcinoma ✓
- C Thymoma
- D Ovarian teratoma
Correct answer: B. Breast carcinoma
Explanation
Anti-Ri (ANNA-2) antibodies target Nova-1 RNA-binding proteins expressed in neurons and certain breast cancer cells, most classically causing paraneoplastic opsoclonus-myoclonus. The tumor most associated is breast carcinoma (occasionally gynecologic cancers). ANNA-1 (anti-Hu) is linked to small cell lung carcinoma. Anti-NMDAR encephalitis is associated with ovarian teratoma. Thymoma is associated with anti-AChR and anti-muscle-specific kinase antibodies leading to myasthenia gravis.
Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
Written and medically reviewed by the StethoPrep medical team.