Calretinin, inhibin, and SF-1 are the most useful immunohistochemical markers for confirming a diagnosis of:

• A Yolk sac tumor
• B Sertoli-Leydig cell tumor
• C Fibrothecoma
• D Granulosa cell tumor ✓

Explanation

Granulosa cell tumors are sex cord-stromal tumors that strongly express calretinin (a calcium-binding protein), inhibin (alpha subunit), and SF-1 (steroidogenic factor 1, a nuclear receptor). This panel distinguishes them from epithelial ovarian tumors. Sertoli-Leydig tumors also express these markers but differ in morphology and clinical presentation. Yolk sac tumors express AFP and SALL4. The combination of calretinin + inhibin + SF-1 positivity with Coffee-bean nuclei and Call-Exner bodies is diagnostic of granulosa cell tumor.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.