A 35-year-old woman presents with asthma, peripheral eosinophilia, and mononeuritis multiplex. Chest X-ray shows transient patchy pulmonary infiltrates. Labs show elevated p-ANCA (MPO). What is the most likely diagnosis?
- A Granulomatosis with polyangiitis (Wegener's)
- B Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) ✓
- C Microscopic polyangiitis
- D Polyarteritis nodosa
Correct answer: B. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
Explanation
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) is characterized by asthma, eosinophilia, and vasculitis with mononeuritis multiplex, associated with p-ANCA (MPO). GPA is associated with c-ANCA/PR3 and shows necrotizing granulomas with upper airway involvement. Microscopic polyangiitis lacks asthma and eosinophilia. PAN does not involve the lungs or associate with ANCA.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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