A previously healthy 22-year-old man converts his tuberculin skin test to positive. Chest radiograph shows a 1.5 cm subpleural nodule in the right mid-lung zone with ipsilateral hilar lymphadenopathy. This combination constitutes:
- A Ranke complex
- B Simon focus
- C Ghon complex ✓
- D Assmann focus
Correct answer: C. Ghon complex
Explanation
The Ghon complex is the lesion of primary tuberculosis: a peripheral parenchymal focus (Ghon focus), usually subpleural in the upper part of a lower lobe or lower part of an upper lobe, together with involved draining hilar lymph nodes. With healing and calcification it becomes the Ranke complex. The Simon focus is a hematogenous apical lesion, and the Assmann focus is the apical lesion of secondary TB.
Reference: Harrison's Principles of Internal Medicine, 21st ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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