A 25-year-old woman with SLE develops recurrent venous and arterial thrombosis, thrombocytopenia, and a history of recurrent miscarriages. The most likely associated antibody is:
- A Anti-dsDNA
- B Anticardiolipin ✓
- C Anti-Sm
- D Anti-Ro/SSA
Correct answer: B. Anticardiolipin
Explanation
The combination of thrombosis, thrombocytopenia, and recurrent pregnancy loss suggests antiphospholipid syndrome, commonly associated with SLE. Anticardiolipin antibodies (along with lupus anticoagulant and anti-beta-2 glycoprotein I) are the diagnostic markers. Anti-dsDNA and anti-Sm are SLE-specific but not thrombogenic. Anti-Ro/SSA is associated with neonatal lupus.
Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.
High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP
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