A 7-year-old boy develops periorbital edema and tea-colored urine 2 weeks after a streptococcal throat infection. Renal biopsy shows subepithelial hump-shaped deposits on electron microscopy. The immune deposits in this condition are composed mainly of:

• A IgA and C3
• B IgE and C4
• C IgM and C1q
• D IgG and C3 ✓

Explanation

Post-streptococcal glomerulonephritis is an immune complex-mediated (type III) hypersensitivity disease. Characteristic subepithelial hump-shaped deposits contain IgG and C3. IgA and C3 deposits are seen in IgA nephropathy. IgM and C1q are not characteristic of this disease. IgE is involved in type I hypersensitivity reactions.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.