A 4-year-old boy presents with recurrent sinopulmonary infections with encapsulated organisms, atopic eczema, and thrombocytopenia with small-sized platelets. The most likely diagnosis is:

• A X-linked agammaglobulinemia (Bruton disease)
• B Hyper-IgM syndrome
• C Chédiak-Higashi syndrome
• D Wiskott-Aldrich syndrome ✓

Explanation

The classic triad of Wiskott-Aldrich syndrome includes eczema, thrombocytopenia with small platelets, and recurrent infections. XLA causes recurrent pyogenic infections but lacks thrombocytopenia and eczema. Chédiak-Higashi presents with partial albinism and giant granules. Hyper-IgM syndrome involves normal or large platelets and defective class switching.

Reference: Robbins and Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.