Goodpasture syndrome involves autoantibodies against which specific antigen, and what hypersensitivity type is this?

• A Alpha-5 chain of type IV collagen; Type II hypersensitivity
• B Laminin-beta2; Type III (immune complex) hypersensitivity
• C Alpha-3 chain of type IV collagen (NC1 domain); Type II (cytotoxic) hypersensitivity ✓
• D Podocin; Type IV (delayed) hypersensitivity

Explanation

Goodpasture syndrome is caused by IgG autoantibodies against the NC1 domain of the alpha-3 chain of type IV collagen, expressed in the GBM and alveolar basement membrane. This is Type II (cytotoxic) hypersensitivity — antibody binding activates complement, recruits neutrophils, and causes crescentic GN with pulmonary hemorrhage. Linear IgG deposits on immunofluorescence are pathognomonic. Alpha-5 type IV collagen is the Alport syndrome target, not Goodpasture.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

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