In systemic lupus erythematosus (SLE), wire-loop lesions in glomeruli represent:

• A Massive subendothelial immune complex deposits causing capillary wall thickening ✓
• B Fibrin thrombi occluding glomerular capillaries
• C Proliferation of mesangial cells compressing capillary lumens
• D Amyloid deposits in glomerular capillary walls

Explanation

Wire-loop lesions are a histological hallmark of Class IV (diffuse proliferative) lupus nephritis on light microscopy, representing massive subendothelial immune complex deposits that cause severe thickening of capillary walls, giving them a rigid, 'wire-loop' appearance. These large subendothelial deposits are visible on EM and are rich in IgG and complement. This signifies severe renal involvement with poor prognosis without treatment.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.