In AL amyloidosis, the amyloid fibrils are derived from which precursor protein?

• A Monoclonal immunoglobulin light chains (kappa or lambda) ✓
• B Serum amyloid A (SAA), an acute phase reactant
• C Beta-2 microglobulin from dialysis patients
• D Transthyretin (TTR) in familial or senile amyloidosis

Explanation

AL (amyloid light chain) amyloidosis, the most common systemic amyloidosis, is derived from misfolded monoclonal immunoglobulin light chains, usually lambda > kappa, produced by plasma cell dyscrasias (myeloma, MGUS). AA amyloidosis uses SAA as precursor. Beta-2 microglobulin causes dialysis-related amyloid. Transthyretin causes hereditary (ATTR) or senile systemic amyloidosis.

Reference: Robbins & Cotran Pathologic Basis of Disease, 10th ed.

High-yield for: NEET PGINI-CETNExTFMGEUSMLEPLABMRCP

Written and medically reviewed by the StethoPrep medical team.